Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition
نویسندگان
چکیده
منابع مشابه
Lead exposure during synaptogenesis alters vesicular proteins and impairs vesicular release: potential role of NMDA receptor-dependent BDNF signaling.
Lead (Pb(2+)) exposure is known to affect presynaptic neurotransmitter release in both in vivo and cell culture models. However, the precise mechanism by which Pb(2+) impairs neurotransmitter release remains unknown. In the current study, we show that Pb(2+) exposure during synaptogenesis in cultured hippocampal neurons produces the loss of synaptophysin (Syn) and synaptobrevin (Syb), two prote...
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ژورنال
عنوان ژورنال: NeuroToxicology
سال: 2011
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2010.12.013